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Cagrilintide
Basic Info.
Cagrilintide, a long-acting analogue of the hormone amylin, presents a promising new approach to tackling obesity. Unlike many weight-loss drugs that only target one mechanism, cagrilintide works on multiple fronts. It suppresses appetite by promoting feelings of fullness (satiety) and slows down gastric emptying, making people feel full for longer periods of time.
Early trials of cagrilintide have shown that it leads to significant weight loss compared to placebo and even other peptides like liraglutide, which is currently used for obesity treatment. In one study, participants taking cagrilintide lost up to 10.8% of their body weight over 26 weeks, outperforming those on liraglutide.
Sustained weight loss like this can help break the cycle of yo-yo dieting.
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Ara-290
Basic Info.
ARA 290, a
Nonerythropoietic Peptide Engineered from Erythropoietin, Improves Metabolic
Control and Neuropathic Symptoms in Patients with Type 2 Diabetes. ARA 290 has been shown to be effective in the reduction of inflammation and activation of the healing process in a wide variety of preclinical models as well as in patients.
With respect to diabetes, substantial recent work has shown that rhEPO can improve the diabetic state in animal models . However, in addition to interacting with the innate repair receptor in a paracrine/autocrine manner, EPO also functions as a circulating hormone via its interaction with the EPO receptor homodimer that mediates hematopoiesis.
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Cerebrolysin
Basic Info.
Cerebrolysin, a neuropeptide preparation, has been extensively studied in rat models to evaluate its potential in treating neurological impairments. Research indicates that Cerebrolysin can significantly enhance cognitive functions and promote neuroprotection following brain injuries.
It is rats subjected to mild traumatic brain injury (mTBI) were treated with Cerebrolysin. The results demonstrated notable improvements in long-term spatial learning and memory, as assessed by the Morris water maze test.
Additionally, treated rats exhibited reduced accumulation of amyloid precursor protein and decreased astrogliosis, suggesting neuroprotective effects.
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